There is great interest in finding relationships between drugs and adverse events through retrospective exploration of existing observational databases.

Methods that can correctly classify drug-condition relationships as true or false associations could greatly contribute to the current pharmacovigilance practice by providing all key stakeholders additional information to inform therapeutic decision-making. This challenge seeks analysis methods that, given an observational database containing multiple different types of drugs and conditions, can identify the relationship between all drug-condition pairs.

Grand Prize: 1st place on March 31, 2010 $10,000 Progress Prize: 1st place on November 30, 2009 $2,500 Progress Prize: 2nd place on November 30, 2009 $1,000

Challenge 1 Description (pdf) OMOP Cup Rules (pdf) Common Data Model

Data Files: Some unzip utilities do not support large files. If yours is unsuccessful, try 7zip. OMOPChallenge1.zip (3.8 GB, contains four tab-separated text files, ~18 GB uncompressed. MD5SUM (?)) OMOP_TRUE_RELATIONSHIPS.txt